Mycology Research Today is a free monthly online journal that collates and summarizes the latest research about Mycology, including details on fungi, diseases, identification, microscopy.

Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01.

Kasettrathat C, Ngamrojanavanich N, Wiyakrutta S, Mahidol C, Ruchirawat S, Kittakoop P

Chulabhorn Research Institute and Chulabhorn Graduate Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand; Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.

Nodulisporacid A (1) was isolated from a marine-derived fungus Nodulisporium sp. CRIF1, while vermelhotin (5) was obtained from an unidentified fungus CRI247-01 (a member of the Order Pleosporales). Both 1 and 5 occurred as equilibrium E/Z mixtures. Ester derivatives (2 and 3) and vermelhotin (5) showed cytotoxic activity against eleven cancer cell lines. Nodulisporacid A (1) and vermelhotin (5) exhibited moderate antiplasmodial activity.

Published 22 September 2008 in Phytochemistry.
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